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Objective:To explore the association between glutamyl transpeptidase (GGT) trajectories and new-onset metabolic syndrome to provide insights for the prevention and treatment of metabolic syndrome.Methods:A total of 3 209 subjects who met the inclusion criteria were enrolled in the study cohort of physical examination population. The GGT levels before follow-up were classified by R LCTMtools program into 3 GGT trajectory groups: low-stable group, medium-stable group and high-stable group. Cox proportional hazards regression model was used to analyze the correlation between different GGT trajectories and new-onset metabolic syndrome.Results:At the end of follow-up in 2020, the cumulative incidence of metabolic syndrome was 7.0%, and the incidence of metabolic syndrome in the low-stable group, medium-stable group and high-stable group were 3.9%, 11.4%, and 15.0%, respectively, showing a growth trend ( P<0.001). After adjusting for multiple confounding factors by Cox proportional hazards regression model, the risk of metabolic syndrome in medium-stable group and high-stable group increased in the total population. The hazard ratios (95% CI)for the high stable group in males and the medium-stable group in females were 1.67(1.07-2.60) and 3.29(1.14-9.53), respectively, compared with their respective low-stable group. Conclusion:Elevated longitudinal trajectory of GGT is a risk factor for new-onset metabolic syndrome, the risk of metabolic syndrome in the total population increased with the increase of long-term GGT level. It is recommended to maintain the long-term level of GGT at about 28 U/L in males and 14 U/L in females, respectively, to achieve the goal of early prevention of metabolic syndrome.
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Objective To discuss the manifestations of MRI of enlarged iliopsoas bursa.Methods MRI features of enlarged iliopsoas buras were studied retrospectively proved by aspiration of synovial fluid under ultrasound guidance or surgical operation-pathology or clinical followed up and with typical MRI findings in 13 cases were analysed retrospectively.Results 13 enlarged iliopsoas bursas all located at the level of or part of the acetabulum sections in only one side(right side in 5 and left side in 8).The largest cyst was 7.0 cm in diameter.All of them appeared as round,oval,upside-down water drop-like or irregular multilocular cystic shadow and located posterolateral to the external iliac blood vessels and or femoral blood vessels,medial to iliopsoas muscle(tendon),and anterior to hip joint capsule.The cysts were hypo-or iso-intensity on T1WI and water-like high signal intensity on T2WI and markedly higher signal intensity on STIR,it was difficult to identify the cystic wall on plain scans.5 cases underwent contrast-enhanced MR scan,the cystic wall had linear slight to moderate homogeneous enhancement in 3,no enhancement in one and irregular multilocular enhancement in one who was with simple purulent synovitis.2 cases were simple synovitis,11 cases accompanied by hip joint disease.Conclusion MRI is of important value in diagnosing the enlarged iliopsoas bursa.
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Objective To investigate the effect of diet and gene on blood-fat trait of the individual.Method One hundred and twenty mice were fed with high fat emulsion for 4 w,then the genotypes of LPL were analyzed by PCR-SSCP to investigate their effect on blood-fat traits and some organ performance of mice.Result After fed with high fat emulsion for 4 w,98 mice suffered from hyperlipidemia,while 22 mice did not.And a G/A mutation was found in 220 targeted fragments we amplified at 14355 site,and association analysis showed that the mice with BB genotype had higher TC、TG、LDL、H/W、L/W level than those of the mice with AA genotype(P